Grand Ohio River (St. Louis to Pittsburgh)

Start your journey in this unique city with frontier-town roots and Midwest modesty.

St. Louis is sure to win you over. Admire the scenic riverfront, highlighted by the majestic Gateway Arch, the largest man-made monument in the U.S. Enjoy St. Louis’ many world-class attractions, including the Art Museum, Science Center, and the Missouri History Museum. End your day at the Missouri Botanical Garden, one of the world’s most popular public gardens.

Perched on the western bank of the Mississippi River, Cape Girardeau is a town reminiscent of the days of pioneers, steamboats, and trading posts. You will feel as if you have stepped back in time, in this enchanting place which has been visited by the likes of Mark Twain, Lewis and Clark, and Ulysses S. Grant. Explore the impressive murals that decorate the historic downtown and chronical its past and unique relationship with Ole Man River. Peruse the many antique and specialty shops to find the perfect souvenir.

Residing at the confluence of the Tennessee River and the Ohio River, Paducah will make you feel as if you stepped back in time. As you walk the streets of this Chickasaw village site, discover Paducah’s rich history. View the Wall-to-Wall Mural Program, a collection of over 50 murals that covers a number of subjects including Native American history, the Civil War, and area landmarks such as the Old Carnegie Library.

Discover this delightful riverside city which is the perfect blend of modern and historic architecture. Evansville is home to Bally's Evansville, the state's first casino, as well as Mesker Park Zoo and Botanic Garden, one of the state’s oldest and largest zoos. Explore the area’s many museums and take time for shopping and strolling along the charming streets of this picturesque waterfront town.

You won’t miss the presence of the notable resident, John James Audubon, whose “Birds of America” paintings are recreated as bronze statues throughout Henderson. Named after President Washington’s home on the Potomac, this bucolic river town is steeped in fascinating lore. Let our expert guide lead you on a tour of our famous first President's historic home and grounds.

As our riverboat makes its way to Louisville, admire the city's architecture which is a blend of old and new. Named after King Louis XVI of France, Louisville is best known for the famed Kentucky Derby, the first leg of the Triple Crown of Thoroughbred Racing.

Spend another day in Kentucky, known as the "Bluegrass State," due to the bluegrass found in many of its pastures because of the fertile soil. On the Louisville Downtown Shuttle, explore the Old Louisville neighborhood, the largest historic preservation district in the U.S., solely featuring Victorian homes and buildings.

Enjoy a visit to Cincinnati, a vibrant city and cultural center which boasts two major sports franchises, a zoo and botanical garden, and numerous theaters and museums. Stroll along its picturesque streets, abounding in eclectic architecture and shop at the famous Findlay Market, a longtime gathering place for vendors to sell local goods, meats, and fresh produce.

Spend a second day in this mesmerizing city. Explore The Cincinnati Museum Center, which encompasses history, science, and children's museums in the art deco Union Terminal. View picturesque Eden Park, home of the Cincinnati Art Museum, Playhouse in the Park, and Krohn Conservatory.

Maysville is a quaint town with a rich history. An important stop on the Underground Railroad, Maysville was host to Harriet Beecher Stowe in 1883. Your stop will include idyllic country scenery and the native sounds of original bluegrass country music.

The second-largest city in the Parkersburg-Marietta-Vienna Metropolitan area, Marietta was named in honor of Marie Antoinette. During the 18th and 19th century, the town experienced economic prosperity, as its location on the Ohio River made it an attractive stop for commercial steamboats, as well as travelers.

End your journey in the "steel city," Pittsburgh, PA. Long known for steel manufacturing, Pittsburgh was an essential stop along the Ohio River for national and international commerce making it a wealthy town in the 18th and 19th centuries. As you cruise the Ohio River delight in picturesque and ever-changing scenery, as early explorers did centuries ago.